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Table of Contents

Volume 54 Issue 12 June 15, 2012

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

NEWS

IN THE LITERATURE

IDSA GUIDELINES

ARTICLES AND COMMENTARIES

  • Gastrointestinal basidiobolomycosis is an emerging invasive fungal infection in the southwestern US desert and in other arid regions worldwide. Clinical findings often mimic malignancy or inflammatory bowel disease. Combined surgical excision and antifungal therapy appears to be beneficial.

  • We determined host and pathogen risk factors for urinary-source bacteremia in a prospective study of patients with Escherichia coli bacteriuria. Both host (urinary retention; history of urogenital surgery) and pathogen factors (a capsule characteristic) were independent predictors of bacteremia.

  • This meta-analysis demonstrates significant increases in mortality and noncures with tigecycline versus comparator antibiotics. Tigecycline should not be used as the principal agent to treat serious infections for which other active antibiotics are available.

  • The indispensable criteria for diagnosis of human T-cell lymphotropic virus type 1 (HTLV-1)–associated infective dermatitis are (1) presence of erythematous-scaly and crusted lesions involving ≥3 areas, including scalp and retroauricular regions; (2) recurring nature of the lesions; and (3) a finding of HTLV-1 infection.

  • In critically ill patients with otherwise untreatable nosocomial infection due to gram-negative bacteria susceptible only to colistin, a high-dose, extended-interval colistin dosing regimen is, according to the pharmacokinetic/pharmacodynamic behavior of the drug, associated with low renal toxicity and high efficacy.

  • This is the first detailed analysis involving a North American pertussis outbreak since introduction of acellular vaccine. Disease was widespread among fully vaccinated preadolescents. Approximately 3 years after vaccination, attack rates markedly increased, suggesting inadequate vaccine protection or durability.

  • The risk of death is exceptionally high among patients with septic shock attributed to Candida infection, especially among patients with inadequate source control and delayed antifungal treatment.

  • Human immunodeficiency virus (HIV)–infected African Americans (AAs) may have a higher risk of cardiovascular complications. Our study suggests that vitamin D deficiency Is independently associated with silent coronary artery disease (CAD) in HIV-infected AAs without symptoms/clinical evidence of CAD. Further longitudinal studies are needed.

VIEWPOINTS

REVIEW ARTICLE

  • Reduced rates of consultations for otitis media after introduction of pneumococcal conjugate vaccines (PCVs) have been overinterpreted. This systematic review suggests that PCV is only somewhat modestly effective against all-cause otitis media.

BRIEF REPORTS

PHOTO QUIZ

INVITED ARTICLES

IMMUNOCOMPROMISED HOSTS

MEDICAL MICROBIOLOGY

HIV/AIDS

  • Discordance between absolute CD4 cell count and CD4 cell percentage is common in patients coinfected with human immunodeficiency virus and hepatitis C virus. Discordance is associated with markers of fibrosis, an aspartate transaminase to platelet ratio index of >1.5, and end-stage liver disease and thus may be useful in identifying patients for liver disease staging.

  • In cross-sectional analysis of 287 human immunodeficiency virus–infected persons with high hepatitis C virus prevalence, liver fibrosis defined by elastography was associated with higher CD4+ T-cell percentages relative to absolute CD4+ number; this discordance was most apparent in persons with marked lymphopenia.

ANSWER TO THE PHOTO QUIZ

CORRESPONDENCE

ELECTRONIC ARTICLE

  • We identified baseline (before chemotherapy) and early nonbaseline prognostic factors for neutropenia-related invasive aspergillosis in myeloma patients. Higher baseline platelet count and creatinine clearance rate and normalization of serum galactomannan level ≤7 days after the first positive serum Aspergillus galactomannan index were associated with better outcome.

COVER/STANDING MATERIAL

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

June 15, 2012